胡椒碱抗实验性胃溃疡的作用

目的：研究胡椒碱抗大鼠或小鼠实验性胃溃疡的作用。方法：实验性胃溃疡是由应激、吲哚美辛、盐酸和幽门结扎引起,实验前5h ig胡椒碱。结果：胡椒碱25、50、100mg/kg能抑制大鼠或小鼠胃粘膜损伤,对应激性型胃粘膜损伤,抑制率分别为16．9％,36．0％,48．3％;吲哚美辛型胃粘膜损伤为4．4％,51．1％,64．4％;盐酸型胃粘膜损伤为19．2％,41．5％,59．6％;对幽门结扎型胃粘膜损伤为4．8％,11．9％,26．2％;胃液分泌减少;胃酸、胃蛋白酶活性降低。结论：胡椒碱具有抗实验性胃溃疡作用。

Protective action of piperine against experimental gastric ulcer

AIM: To study the effects of piperine (Pip) on several experimental gastric ulcers in rats and mice. METHODS : The gastric mucosa damage was induced by stress, indometacin, HC1, and pyloric ligation in rats or mice. The number of gastric ulcers, the volume and acidity of gastric juices, and pepsin A activity were detected. RESULTS: Pip 25, 50, 100 mg/kg ig protected animals from gastric ulceration in a dose-dependent manner. The inhibitory rates were 16.9 % , 36.0 % , and 48.3 % in stress ulcers; 4.4 %, 51.1 %, and 64.4 % in indometacin ulcers; 19.2 %, 41.5 %, and 59.6 % in HCl ulcers; 4.8 %, 11.9 %, and 26.2 % in pyloric ligation ulcers, respectively; Pip inhibited the volume of gastric juice, gastric acidity, and pepsin A activity. CONCLUSION: Pip has the protective effects against gastric ulceration.