Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units |
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| Authors: | Pierre?Delanaye,Bernard?Lambermont mailto:b.lambermont@chu.ulg.ac.be" title=" b.lambermont@chu.ulg.ac.be" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Jean-Paul?Chapelle,Jacques?Gielen,Paul?Gerard,Georges?Rorive |
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| Affiliation: | (1) Nephrology, Department of Medicine, Liege University Hospital, CHU Sart Tilman (B35), 4000 Liege, Belgium;(2) Medical Intensive Care Unit, Department of Medicine, Liege University Hospital, CHU Sart Tilman (B35), 4000 Liege, Belgium;(3) Department of Clinical Chemistry, Liege University Hospital, CHU Sart Tilman (B35), 4000 Liege, Belgium;(4) Department of Statistics, University of Liege, 4000 Liege, Belgium |
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| Abstract: | ![]()
Objective To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.Design Prospective observational study.Setting Medical intensive care unit at a university hospital.Patients and participants Fourteen patients hospitalised in a medical intensive care unit.Interventions Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h.Measurements and results Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m2 was significantly better than that of creatinine (p<0.05).Conclusions Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future. |
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| Keywords: | Creatinine Critical care Cystatin C Glomerular filtration rate Kidney function tests |
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