反复玻璃体内注射阿柏西普对黄斑水肿患者角膜的影响

目的　观察反复玻璃体内注射阿柏西普对黄斑水肿患者的角膜内皮细胞和中央角膜厚度的影响。方法　选取2018年3月至2020年10月在我院行玻璃体内注射阿柏西普治疗黄斑水肿的患者46例46眼。每位患者均接受玻璃体内注射阿柏西普2 mg/0.05 mL，每月1次，连续注射3次。对比分析注药前1 d和注药后1个月、3个月、5个月患眼眼压、中央角膜厚度、角膜内皮细胞密度、六边形细胞比例、角膜内皮细胞面积变异系数和角膜内皮细胞数的变化。结果　注药前1 d和注药后1个月、3个月、5个月患眼中央角膜厚度分别为（538.85±31.87）μm、（536.02±30.87）μm、（535.43±31.48）μm、（536.46±32.50）μm，差异无统计学意义（P>0.05）。注药前1 d和注药后1个月、3个月、5个月，患眼眼压差异无统计学意义（P>0.05）。注药前1 d和注药后1个月、3个月、5个月患眼角膜内皮细胞密度分别为（2678.72±421.72）个·mm^-2、（2658.30±461.71）个·mm^-2、（2661.96±407.26）个·mm^-2、（2656.41±427.74）个·mm^-2，差异无统计学意义（P=0.611）。注药前和注药后1个月、3个月、5个月相比，患眼六边形细胞比例、角膜内皮细胞面积变异系数、角膜内皮细胞数差异均无统计学意义（均为P>0.05）。结论　反复玻璃体内注射阿柏西普，短期内对角膜内皮细胞的形态和中央角膜厚度没有明显影响。

Effect of repeated intravitreal aflibercept injections on the cornea in patients with macular edema

Objective To observe the effects of repeated intravitreal aflibercept injection(IAI)on the corneal endothelium and center corneal thickness in patients with macular edema.Methods IAI was performed on 46 eyes of 46 patients with macular edema from Mar.2018 to Oct.2020.Each patient received IAI 2mg/0.05mL monthly for three consecutive months.Intraocular pressure,central cornea thickness,corneal endothelial cell density,percentage of hexagonal cells,coefficient of variation of cell area,and number of endothelial cells in the treated eyes 1 day before injection and 1 month,3 months and 5 months after injection were analyzed.Results The center corneal thickness of the treated eyes were(538.85±31.87)μm 1 day before surgery,and(536.02±30.87)μm,(535.43±31.48)μm,(536.46±32.50)μm at month 1,3 and 5 after injection,respectively,with no statistical significance(P>0.05).There were no statistically significant differences in intraocular pressure 1 day before injection and 1 month,3 months,and 5 months after injection(all P>0.05).The endothelial cell density were(2678.72±421.72)cells·mm^-21 day before injection,and(2658.30±461.71)cells·mm^-2,(2661.96±407.26)cells·mm^-2,(2656.41±427.74)cells·mm^-2,at month 1,3 and 5 after injection,respectively(P=0.611).Percentage of hexagonal cells,coefficient of variation of cell area,and number of endothelial cells in the treated eyes at baseline and month 1,3 and 5 after injection were compared,and there were no significant differences(all P>0.05).Conclusion Repeated IAI monthly for three months seems no effect on corneal endothelial and central cornea thickness at 5 months after IAI.