Phenazines affect biofilm formation by Pseudomonas aeruginosa in similar ways at various scales |
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| Authors: | Itzel Ramos Lars E.P. Dietrich Alexa Price-Whelan Dianne K. Newman |
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| Affiliation: | 1. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. Corrosion and Protection Division, Shenyang National Laboratory for Material Sciences, Northeastern University, Shenyang 110819, PR China;4. Department of Chemical and Biomolecular Engineering, Institute for Corrosion and Multiphase Technology, Ohio University, Athens, OH 45701, USA |
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| Abstract: | Some pseudomonads produce phenazines, a group of small, redox-active compounds with diverse physiological functions. In this study, we compared the phenotypes of Pseudomonas aeruginosa strain PA14 and a mutant unable to synthesize phenazines in flow cell and colony biofilms quantitatively. Although phenazine production does not impact the ability of PA14 to attach to surfaces, as has been shown for Pseudomonas chlororaphis Maddula et al., 2006, Maddula et al., 2008, it influences swarming motility and the surface-to-volume ratio of mature biofilms. These results indicate that phenazines affect biofilm development across a large range of scales, but in unique ways for different Pseudomonas species. |
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