AtxA,a Bacillus anthracis global virulence regulator |
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| Authors: | Agnès Fouet |
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| Affiliation: | 1. M-team and Mastitis and Milk Quality Research Unit, Department of Reproduction, Obstetrics, and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium;2. Animal Genetics Laboratory, Department of Nutrition, Genetics, and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, Merelbeke 9820, Belgium;1. Institut de Systématique Evolution Biodiversité (ISYEB), Muséum national d''Histoire naturelle, CNRS, Sorbonne Université, EPHE, France;2. Laboratoire de Biologie Intégrative des Populations, Evolution Moléculaire, EPHE, PSL University, Paris, France |
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| Abstract: | ![]()
Fifteen years ago, AtxA was isolated as a toxin gene activator and five years later it was shown to be a Bacillus anthracis master regulator. AtxA controls the expression of more than a hundred genes belonging to all genetic elements, the chromosome and both virulence plasmids, including those encoding the major virulence factors. AtxA can activate or repress gene expression. The mechanism by which AtxA exerts its control is unknown; it is indirect on some genes but may be direct on others. The expression of many AtxA-controlled genes is induced by the presence of bicarbonate/CO2. AtxA links the metabolic state and virulence gene expression. |
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