Prevalence and geographic distribution of Hepatitis C Virus genotypes in Indian patient cohort |
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| Authors: | Shobha Narahari Abida Juwle Subhankar Basak Dhananjaya Saranath |
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| Institution: | 1. Medizinische Klinik 1, Goethe University Hospital, Frankfurt, Germany;2. Gilead Sciences, Inc, Foster City, California;3. Beth Israel Deaconess Medical Center, Boston, Massachusetts;4. Swedish Medical Center, Seattle, Washington;5. New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand;6. Texas Liver institute, University of Texas Health Science Center, San Antonio, Texas;1. Department of Research, Institute of Liver & Biliary Sciences (ILBS), Vasant Kunj, New Delhi 110070, India;2. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India;3. Department of Virology, Institute of Liver & Biliary Sciences (ILBS), Vasant Kunj, New Delhi 110070, India;4. Molecular Diagnostics, RAS Lifesciences Pvt. Ltd., Nacharam, Hyderabad, Andhra Pradesh 500076, India;1. Medizinische Klinik 1, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany;2. 1st Division of Gastroenterology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy;3. Division of Infectious Diseases, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden;4. Laboratory of Clinical Chemistry and Microbiology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy;2. Program Officer, Hepatitis C Virus Infection, Punjab, India;3. Department of Internal Medicine, Armed Forces Medical College, Pune 411040, India;1. Division of Viral Diseases, Center for Laboratory Control and Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea;2. Division of Viral Diseases Research, Center for Research of Infectious Diseases, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea;3. Division of Infectious Disease Control, Center for Infectious Disease Control, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea |
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| Abstract: | Viral hepatitis represents a major global health problem with 170 million Hepatitis C Virus (HCV) carriers worldwide, and 12–13 million HCV carriers in India. HCV genotypes are of clinical significance in indicating drug responsiveness and prognosis of the patient. The HCV genotypes are of epidemiologic significance as well, as they are indicative of transmission route of infection and have not been extensively studied in the Indian context. In the current study, HCV genotyping was examined in 2118 patients from different geographic regions of India. HCV was detected by PCR amplification of 5′ UTR and core-envelope1 regions, followed by genotyping using nucleotide sequencing and analysis with NCBI tool (http://www.ncbi.nlm.nih.gov/projects/genotyping/formpage.cgi). HCV genotype distribution in the 2118 Indian patients demonstrated prevalence of HCV3 (3a/3b primarily) in 62% and HCV1 (1a/1b primarily) in 31% patients. The predominance of HCV3 was significant in northern (p = 0.01) and eastern (p = 0.008) regions of India. HCV types 2, 4, 5, and 6 were detected in 0.05–4.5% of the patient group. Thus, our studies demonstrate HCV genotype prevalence in the cohort group in different regions of India. |
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