腹膜透析对重症急性出血坏死性胰腺炎诱发组织器官损害的保护作用

目的探讨腹膜透析(PD)对重症急性出血坏死性胰腺炎(AHNP)诱发组织器官损害的保护作用.方法 34例AHNP患者随机分为PD治疗组(21例)和对照组(13例),对照组采用常规综合治疗方式,PD治疗组除进行常规综合治疗外,还进行间歇性腹膜透析(IPD)治疗.两组均同时监测血TNF-a、IL-1β及血、尿淀粉酶水平,并行血、尿液、大便及透出液常规检查,以及观察肝、肾、心、脑等脏器功能.结果 PD治疗组对脏器组织的保护作用优于对照组,可改善体内炎症状态,患者病死率(14.3%)较对照组(38.5%)低,平均住院天数(20.4±6.3)亦低于对照组(29.7±10.4).结论腹膜透析对重症AHNP诱发的组织器官的损害具有保护作用.

Protective effect of peritoneal dialysis on patients with acute hemorrhagic necrotic pancreatitis

Objective To explore the protective effects of peritoneal dialysis on tissue and organ damage induced by acute hemorrhagic necrotic pancreatitis (AHNP) . Methods Thirty-four AHNP patients were randomly divided into PD group ( n = 21) and control group (n=13). Control group was treated with conventional therapy, while PD group was treated with conventional therapy companied by intermittent peritonea] dialysis (IPD). Urinary and serum amylase, the plasma levels of TNF and IL-1, faecal occult blood test and serum leucocyte were examined. Functions of brain, kidney , liver and heart were observed. Results The protective effect was better in PD group than that in normal group (P<0.05). The survival rate was hihger and the number of hospitalization day decreased in PD group than those in normal group. Conclusion Peritoneal dialysis has a significant protection against tissue and organ damage induced by acute hemorrhagic necrotic pancreatitis.