血管内皮生长因子及其受体与肺发育的研究进展

肺发育受多种因素影响,其中血管内皮生长因子(VEGF)是一种特异作用于血管内皮细胞的生长因子,具有促进血管内皮细胞增殖分化、新生血管形成、增加微血管通透性的功能,并通过其受体介导参与肺血管发育、肺泡形成、表面活性物质合成和肺成熟等,在建立正常肺形态和功能上发挥重要作用,表达异常可致肺发育异常.

The role of vascular endothelial growth factor in lung development

Lung development is affected by many factors, and vascular endothelial growth factor is a specially growth factor which has a broad impact on endothelial cell function, it can promote the proliferation and differentiation of cells,as well as promoting angiogenesis and increasing permeability of micro vascular. Further more, it participates in pulmonary vascular development, alveolarization, surfactant synthesis and lung maturity. Thus vascular endothelial growth factor plays an important role in the establishment of normal lung morphology and function, and its abnormal expression may induce abnormal lung development.