Effect of ethanol on endothelin-1 release from gastric vasculature |
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| Authors: | Eiji Masuda Sunao Kawano Kouichi Nagano Shingo Tsuji Yoshitaka Ishigami Nobuhiko Hayashi Masahiko Tsujii Yoshiaki Sasayama Tomoki Michida Hideyuki Fusamoto et al. |
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| Affiliation: | Eiji Masuda, Sunao Kawano, Kouichi Nagano, Shingo Tsuji, Yoshitaka Ishigami, Nobuhiko Hayashi, Masahiko Tsujii, Yoshiaki Sasayama, Tomoki Michida and Hideyuki Fusamoto, et al. |
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| Abstract: | ![]()
The effects of ethanol on gastric vasculature in isolated vascularly perfused rabbit stomach was investigated. The isolated stomach was perfused with Krebs-Henseleit solution containing 3% dextran bubbled with 95% O2 and 5% CO2 at a rate of 12 ml/min. After mixture and perfusion of 10 mM to 400 mM of ethanol, perfusion pressure and endothelin-1 concentration in effluent from gastric vasculature were measured. Perfusion pressure and endothelin-1 concentration in effluent increased in a dose-dependent manner with increasing ethanol concentrations. In conclusion, the data suggest that ethanol may stimulate the release of endothelin from gastric vasculature and may cause gastric ischemia due to vasoconstriction resulting in acute gastric mucosal injury. |
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