放射性核素标记annexin V凋亡显像在肿瘤研究中的进展

肿瘤细胞凋亡过低是肿瘤形成的重要原因之一,诱导肿瘤细胞凋亡也成了目前抗肿瘤治疗的研究方向。用放射性核素标记的annexin V对细胞凋亡后暴露在细胞膜表面的体内PS(膦脂酰丝氨酸)进行体内显像,可检测早期细胞凋亡。这种体内凋亡显像方法可以监测抗肿瘤治疗的疗效、评估患者的预后,甚至可以指导肿瘤治疗方法的选择,提高治疗的质量。

Advance of apoptosis imaging with radiolabeled annexin V in tumor research

One of the most important reasons that cause tumor is decrease or complete absence of apoptosis of tumor cells.Conversely successful anti-tumor therapy is correlated with the introduction of apoptosis into tumor cells.Radiola-beled annexin V is used to image in vivo the phosphatidylserine(PS)that explode on the outer surface of cell membrane after apoptosis so that apoptosis can be detected on the early stage.This imaging method can be introduced into the re-search of tumor in order to help direct the choose of tumor therapy,inspect the effect and evaluate the prognosis.