ENDOSCOPIC EVALUATION OF THE COMPARATIVE EFFECTS OF ACETYLSALICYCLIC ACID AND CHOLINE MAGNESIUM TRISALICYLATE ON HUMAN GASTRIC AND DUODENAL MUCOSA

A new salicylate product, choline magnesium trisalicylate (Trilisate^®tablets), and acetylsalicylic acid were compared for their localeffects in equipotent doses on the gastroduodenal mucosa ina randomized, double-blind, cross-over study, using 10 healthyvolunteers. After five-day periods of administration, gastroduodenoscopywas performed and photographs were obtained. All subjects givenacetylsalicylic acid developed multiple mucosal lesions, butin only four subjects given choline magnesum trisalicylate wereslight mucosal changes noted. Mean serum salicylate levels weresimilar in the two groups. Our date suggest that the risk ofdeveloping mucosal lesions is much less during treatment withcholine magnesium trisalicylate than with acetylsalicylic acid. KEY WORDS: Aspirin, Choline magnesium trisalicylate, Endoscopic evaluation