| 应用铈细胞化学方法观察镉诱发氧自由基对肾脏的损伤 |
| |
| 引用本文： | 叶煦亭. 应用铈细胞化学方法观察镉诱发氧自由基对肾脏的损伤[J]. 中华预防医学杂志, 1999, 0(2): 3 |
| |
| 作者姓名： | 叶煦亭 |
| |
| 作者单位： | 第二军医大学生物物理研究所 |
| |
| 摘 要： | 目的研究镉及其诱发的氧自由基对肾脏的急性损伤。方法应用电镜细胞化学及能量色散谱分析技术。结果镉离子可进入到肾近曲小管上皮细胞内。肾组织内有氧自由基的过量产生,其主要位于血管内皮细胞,肾近曲小管上皮细胞的线粒体,微绒毛及基底膜等部位。肾近曲小管上皮细胞及线粒体可发生肿胀及内皮细胞脱落等病变。结论镉离子可导致氧自由基的大量形成,从而对肾脏造成损伤。
|
| 关 键 词： | 镉 自由基 肾 过氧化氢 |
Application of Cerium Cytochemical Method in Observation of Renal Injury Caused by Oxygen Free Radical with Cadmium Induction |
| |
| YE Xuting,SHA Jihong,TANG Ying,et al.. Application of Cerium Cytochemical Method in Observation of Renal Injury Caused by Oxygen Free Radical with Cadmium Induction[J]. Chinese Journal of Preventive Medicine, 1999, 0(2): 3 |
| |
| Authors: | YE Xuting SHA Jihong TANG Ying et al. |
| |
| Affiliation: | YE Xuting,SHA Jihong,TANG Ying,et al. Institute for Biophysics,The Second Military Medical University,Shanghai 200433 |
| |
| Abstract: | Objective To study acute renal injury caused by oxygen free radical with cadmium induction. Methods Electron microscopy cytochemical and energy dispersive X ray (EDX) analysis techniques were used. Results Cadmium ions could enter the epithelial cells of renal proximal convoluted tubules. Excessive production of oxygen free radical was found in the kidney tissues, which located mainly in the endothelial cells of blood vessels, mitochondria of epithelial cells of renal proximal convoluted tubules, microvilli and basement membrane. Swelling of epithelial cells and mitochondria and drop of epithelial cells could occur in renal proximal convoluted tubules. Conclusion It suggests that cadmium ions can induce the formation of large amount of oxygen free radical and cause renal injury. |
| |
| Keywords: | Cadmium Free radicals Kidney Hydrogen peroxide |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
