Synaptosomal-associated protein 25 may be an intervention target for improving sensory and locomotor functions after spinal cord contusion |
| |
| Authors: | Zhan-qiong Zhong Yang Xiang Xi Hu You-cui Wang Xi Zeng Xiao-meng Wang Qing-jie Xia Ting-hua Wang Xiao Zhang |
| |
| Affiliation: | 1. Experiment Technology Center of Preclinical Medicine of Chengdu Medical College, Chengdu, Sichuan Province, China;School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China;2. Experiment Technology Center of Preclinical Medicine of Chengdu Medical College, Chengdu, Sichuan Province, China;3. Institute of Neurological Diseases, Center for Translational Neuroscience, Western China Hospital, Sichuan University, Chengdu, Sichuan Province, China |
| |
| Abstract: | ![]()
Synaptosomal-associated protein 25 kDa (SNAP-25) is localized on the synapse and participates in exocytosis and neurotransmitter release. Decreased expression of SNAP-25 is associated with Alzheimer's disease and attention deficit/hyperactivity disorder. However, the expres-sion of SNAP-25 in spinal cord contusion injury is still unclear. We hypothesized that SNAP-25 is associated with sensory and locomotor functions after spinal cord injury. We established rat models of spinal cord contusion injury to detect gene changes with a gene array. A de-creased level of SNAP-25 was detected by quantitative real time-polymerase chain reaction and western blot assay at 1, 3, 7, 14 and 28 days post injury. SNAP-25 was localized in the cytoplasm of neurons of the anterior and posterior horns, which are involved in locomotor and sensory functions. Our data suggest that reduced levels of SNAP-25 are associated with sensory and locomotor functions in rats with spinal cord contusion injury. |
| |
| Keywords: | nerve regeneration synaptosomal-associated protein 25 kDa sensory function locomotor function spinal cord injury gene array neurons neural regeneration |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
