寨卡病毒与登革热病毒交叉反应抗体引发严重性疾病的关系

登革病毒(DENV)不同血清型感染后,易导致抗体依赖增强反应(ADE)的严重性疾病发生。2015年5月巴西流行寨卡病毒(ZIKV)后,截止至2016年11月,流行已扩散到60多个国家和地区,毗邻我国的一些东南亚国家也有报告ZIKV感染病例。近期有研究显示,ZIKV和DENV的包膜(E)蛋白EDI和EDII两表位引发的抗体或由此产生的单克隆抗体具有很强的交叉反应性,易引起ADE的发生。我国沿海省份历年时有DENV病毒流行,今后ZIKV流行事件极有可能发生,因此,由该病毒流行引起的严重性疾病发生我们必须要关注和提出应对措施。

Relationship of severe diseases induced by cross-reactivity antibodies elicited by infection of Zika virus and Dengue virus

Severe infectious diseases,i.e.antibody-dependent enhancement (ADE) resulted from successive infection with different serotypes of dengue virus.After its introduction into Brazil in 2015,Zika virus has spread rapidly to more than 60 countries and regions by the end of November 2016.Some south-east Asian countries including China have also reported cases of ZIKV infection.In recent studies,it was observed that sera cross-reactivity antibodies or such monoclonal antibodies have been elicited by two domains,ED1 and ED2,of envelope (E) protein on Zika or/and Degue virus,and ADE was easily induced by such antibodies.Dengue fever epidemic often occurred in Chinese coastal provinces each year.Then,it will be followed by Zika virus disease.Therefore,we must pay attention to and propose replying measurement for it.