奥硝唑结肠定位片的制备及其体外释放度评价 |
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引用本文: | 周毅生,赵永恒,刘林,秦梅颂.奥硝唑结肠定位片的制备及其体外释放度评价[J].广东医药学院学报,2013(5):469-473. |
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作者姓名: | 周毅生 赵永恒 刘林 秦梅颂 |
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作者单位: | 广东药学院中药学院,广东广州510006 |
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基金项目: | 中山市华南现代中医城(健康医药产业基地)专项发展资金项目立项资助(2007J011) |
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摘 要: | 目的制备奥硝唑结肠定位片,并评价其体外释药情况。方法制备奥硝唑含药片芯,依次包被隔离层、时滞层和肠溶层制备奥硝唑结肠定位片,并考察包衣片的体外释药情况。结果最佳包衣液处方为隔离层增重约1.0%,肠溶层增重3%,PVP用量为60%,Eudragit L100和Eudragit S100质量比为2:3;体外释放度研究表明,制得的奥硝唑结肠定位片在pH1.0 HCl溶液中未释药,在pH6.8的磷酸盐缓冲液中4h累积溶出小于5%,在pH7.6的磷酸盐缓冲液中2h释药大于90%。结论奥硝唑结肠定位片在体外具有结肠定位释放的特性,能达到治疗结肠部位疾病的目的。
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关 键 词: | 奥硝唑 结肠定位片 体外释放度 |
Preparation and in vitro release evaluation of ornidazole colon-specific tablets |
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Authors: | ZHOU Yisheng ZHAO Yongheng LIU Lin QIN Meisong |
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Institution: | ( School of Traditional Chinese Medicine, Guangdong Phmaceutical University, Guangzhou 510006, China) |
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Abstract: | Objective To prepare ornidazole colon-specific tablets and investigate its in vitro release. Methods The colon-target tablet containing ornidazole was coated sequentially with isolated layer, time-dependent layer and outermost enteric coating layer. The in vitro release of coated tablets was investigated in artificial gastrointestinal environment. Results Optimal coating formulation was 1.0% weight gain of isolated layer,3.0% weight gain of enteric coating layer, the dosage of PVPP is 60%, and the proportion of Eudragit LI00 and Eudragit S100 was 2: 3. No release was found in pH 1.0 hydrochloric acid solution,in pH 6.8 phosphate buffer solution (PBS) the amount of release was less than 5% in 4 h and in pH 7.6 PBS the amount of release was more than 90% in 2 hours. Conclusions Ornidazole colon-specific tablets had characteristics of colon-specific release and could treat the disease of colon site. |
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Keywords: | ornidazole colon-target tablet in vitro release |
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