黄芩苷对小鼠急性肝损伤的保护作用

目的 研究黄芩苷对小鼠急性肝损伤的保护作用.方法 给动物灌胃给药,用CCl4、D-半乳糖制作小鼠急性肝损伤模型,用比色分析法测定小鼠血清天冬氨酸转氨酶(aspartate transaminase, ALT)、丙氨酸转氨酶(alanine transaminase, AST)的活性;测定小鼠血清超氧化物歧化酶(superoxide dismutase, SOD)、谷胱甘肽过氧化物酶(glutathione perioxidase, GSH-Px)的活性及丙二醛(malondialdehyde, MDA)的含量.结果 黄芩苷能显著降低因CCl4、D-半乳糖所致急性肝损伤小鼠血清ALT,AST的升高;对急性肝损伤小鼠血清SOD、GSH-Px的活性有明显的升高作用及降低MDA的含量.结论 黄芩苷对CCl4、D-半乳糖所致小鼠急性肝损伤有保护作用.

Protective Effects of Baicalin against Acute Liver Injury in Mice

Objective To study the protective effects of baicalin extract against acute liver injury in mice. Methods Baicalin was perfused stomache to the mice with liver injury by carton tetrachloride and D - galactoasmine. The activities of aspartate transami-nase ( AST) , alanine transaminase ( ALT) , superoxide dismutase (SOD) , glutathione perioxidase (GSH - Px) ; and the content of raalondialdehyde (MDA) in serum were investigated using colorimetric method. Results Baicalin significantly reduced acute liver injury induced by carton tetrachloride and D -galactoasmine, by means of decreasing ALT and AST in serum; the activities of SOD, GSH - Px in treat group were higher than that of model group and the content of MDA in treat group was lower than that of model group, respectively. Conclusion Baicalin has protective effects on mice with acute hepatic injury induced by carton tetrachloride and D - galactoasmine.