Application of Lipid Blend-Based Nanoparticulate Scaffold for Oral Delivery of Antihypertensive Drug: Implication on Process Variables and In Vivo Absorption Assessment |
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| Authors: | Manzar Hasnain Syed Sarim Imam Mohd. Aqil Abdul Ahad Yasmin Sultana |
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| Affiliation: | 1.Department of Pharmaceutics, School of Pharmaceutical Education and Research,Jamia Hamdard (Deemed University),New Delhi,India;2.Department of Pharmaceutics, Glocal School of Pharmacy,Glocal University,Saharanpur,India;3.Department of Pharmaceutics, College of Pharmacy,King Saud University,Riyadh,Saudi Arabia |
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| Abstract: | PurposeThe aim of the present study was to formulate and optimize lipid blend-based olmesartan medoxomil (OLM) loaded nanoparticulate scaffolds (NLCs) for enhanced oral bioavailability.MethodThe OLM-NLCs were formulated using dependent variables in different concentrations of solid lipid, liquid lipid, surfactant, and co-surfactant by using melt emulsification combined with ultrasonication technique. The formulations were experimentally optimized using a three-factor, three-level statistical design approach. The formulated OLM-NLCs were evaluated for various pharmaceutical quality evaluation parameters and further optimized formulation (OLM-NLCopt) was assessed for release kinetics, thermal behavior, and in vivo absorption assessment.ResultThe optimized formulation (OLM-NLCopt) showed particle size (138.7 nm), PDI (0.18), and entrapment efficiency (83.65%). The comparative in vitro release study revealed OLM-NLCopt showed significantly higher ( p? ConclusionThe results of the release study and pharmacokinetic study suggest the potential of OLM-NLCs for improved oral delivery. |
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