血清神经生长因子在糖尿病性周围神经病变发病中的作用

目的 探讨神经生长因子(NGF)在糖尿病性周围神经病变(DNP)发病机制中的作用及其与感觉神经传导速度(SNCV)的相关性. 方法 41名临床确诊为DNP的患者、35名患糖尿病但无DNP的患者及33名健康对照者应用酶联免疫吸附法测量血清NGF水平及左侧正中神经、尺神经、腓神经和胫神经SNCV,进行相关分析. 结果 DNP组患者血清NGF水平为(665.18±188.32)ng/L,显著低于健康对照组(976.44±159.07)ng/L和糖尿病不伴DNP组(943.32±167.33)ng/L(F=9.316,P<0.001),DNP患者NGF水平与正中神经和腓神经SNCV之间呈正相关(r=0.810,0.760,均P<0.001),NGF水平下降程度与DNP病程之间呈正相关(r=0.542,P<0.001). 结论 DNP患者血清NGF水平低于健康者,NGF合成下降在DNP的发病机制中起一定的作用.

The role of nerve growth factor in the pathogenesis of diabetic neuropathy

Objective To investigate the role of nerve growth factor (NGF) in the pathogenesis of diabetic neuropathy (DNP) and the correlation of NGF level with,sensory nerve conduction velocity (SNCV) and duration of DNP. Methods The 41 patients with DNP,35 diabetics without DNP and 33 healthy controls were enrolled.And the serum level of NGF was measured with ELISA,the SNCV of left medial nerve,ulnar nerve,peroneal nerve and tibial nerve were measured too. Then the correlation analysis was completed. Results The serum level of NGF was significantly lower in DNP patients [(665.18±188.32) ng/L] than in healthy controls [(976.44±159.07)ng/L] and in diabetics without DNP [(943.32±167.33) ng/L,F=9.316,P<0.001].The NGF level of DNP patients was positively correlated with SNCV of left medial nerve (r=0.810,P<0.001 ),left peroneal nerve (r=0.760,P<0.001) and duration of DNP (r=0.542,P<0.001).Conclusions The serum level of NGF is lower in DNP patients than in healthy controls.The decrease of the production of NGF may play a role in the pathogenesis of DNP.