| ������ͨ�����ⶨ�������о� |
| |
| 引用本文： | �Ų���,�ƺ�ΰ,�⽨��,Ҧ��,�����. ������ͨ�����ⶨ�������о�[J]. 中国药学杂志, 2015, 50(19): 1721-1725. DOI: 10.11669/cpj.2015.19.014 |
| |
| 作者姓名： | �Ų��� �ƺ�ΰ �⽨�� Ҧ�� ����� |
| |
| 作者单位： | ?й????????о??,???? 100050 |
| |
| 摘 要： |
|
| 关 键 词： | ??????? ?????? ???????? ??Ч??????? |
Content Determination Method of Crotamiton |
| |
| ZHANG Cai-yu,HUANG Hai-wei,WU Jian-min,YAO Jing,HU Chang-qin. Content Determination Method of Crotamiton[J]. Chinese Pharmaceutical Journal, 2015, 50(19): 1721-1725. DOI: 10.11669/cpj.2015.19.014 |
| |
| Authors: | ZHANG Cai-yu HUANG Hai-wei WU Jian-min YAO Jing HU Chang-qin |
| |
| Affiliation: | National Institute for Food and Drug Control, Beijing 100050, China |
| |
| Abstract: | ??OBJECTIVE To study the content determination method of crotamiton. METHODS The quantitative mass balance method, HPLC external standard method and nuclear magnetic resonance(QNMR) were used to determine the content of crotamiton, respectively. The accuracy of the three methods was evaluated. RESULTS The contents of crotamiton were 99.2%,102.9% and 99.1% respectively as determined by the three different methods. CONCLUSION Because the ultraviolet absorption coefficients of cis- and trans-crotamiton might be different, the current pharmacopoeia method, ie, using integrated peak areas to calculate the content, is questionable. QNMR method can measure the contents of cis- and trans-crotamiton respectively, so it can be a complementary method to establish the reference standard. |
| |
| Keywords: | |
|
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药学杂志》下载全文 |
|
