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Analysis of Foscarnet-induced Adverse Drug Reaction in Beijing Area from 2008 to 2014

??OBJECTIVE To analyze the reports of foscarnet-induced adverse drug reaction (ADR) in Beijing area in the recent 6 years, and to provide reference for rational use of foscarnet.METHODS One hundred and fifty-two reports of ADR from March 2008 to December 2014 induced by foscarnet received by Beijing drug adverse reaction monitoring center were collected. The type and time of ADR,the age of patient, the gender and nation of patient, serious adverse reactions, allergy history, administration, dosage, preparation, the indication,ADR history,ADR involved organ and system ,the causal relationship, treatments and prognosis were retrospectively analyzed.RESULTS The ADR induced by foscarnet were more often occurred in patients aged from 31 to 60, with 55.3% appearing within 24 h after drug use. The clinical presentation was complex and diverse, which involved different systems and organs, predominantly the lesion of renal function and epilepticseizures.CONCLUSION Safe to use with foscarnet is worth paying attention by clinicans, who should detect and deal with ADR of foscarnet in time on basis of rational use.