地氟醚与七氟醚对颅脑肿瘤手术患者血糖和乳酸的影响

目的研究地氟醚与七氟醚对颅脑肿瘤手术患者血糖和乳酸的影响。方法选择择期行颅脑肿瘤切除的患者64例,年龄21～62岁,ASA分级Ⅰ～Ⅱ级,体质指数20～25 kg/m2,采用随机数字表法分为地氟醚组(Group Des,n=30)与七氟醚组(Group Sevo,n=34),分别采用地氟醚、七氟醚吸入麻醉。分别于手术前(T0)、手术1小时(T1)、手术2小时(T2)、手术结束(T3)取动脉血1 m L,检测血糖和乳酸水平。结果两组患者血糖均升高,在四个不同时间点的比较差异有统计学意义(P0.01);各组在各时间点的比较无统计学意义(P0.05)。两组患者乳酸无明显升高,在各时间点的比较无统计学意义(P0.05);各组在各时间点的比较无统计学意义(P0.05)。结论地氟醚与七氟醚麻醉均增加颅脑肿瘤患者血糖水平。

Effects of desflurane and sevoflurane anesthesia on levels of blood glucose and lactic acid in brain tumor patients

［Abstract］ Objective To investigate the effects of desflurane and sevoflurane on blood glucose and lactic acid in patients with brain tumor. Methods Sixty four patients with brain tumor, aged 21-62 yr, American Society of Anesthesiologists status Ⅰ-Ⅱ, with body mass index of 20-25, scheduled for brain tumor resection surgery, were assigned into desflurane group（Group Des, n=30）and sevoflurane group （Group Sevo, n=34）using a random number table, the two groups were anesthetized with desflurane and sevoflurane respectively. 1 mL artery blood sample were taken to detect the levels of blood glucose and lactic acid at each time of before operation（T0）, one hour after operation（T1）, two hours after operation（T2）, end of operation（T3）. Results The level of blood glucose in both group were significant increased（P<0.01）, but there were no statistical difference between the two groups（P>0.05）. There were no significant increase on the level of lactic acid in both group（P>0.05）, also, no statistical difference between the two groups （P>0.05）. Conclusion Both desflurane and sevoflurane anesthesia increase blood glucose levels in patients with brain tumors.