抗艾滋病药物靶向递送系统的研究进展

抗艾滋病药物的发现及使用有效地延长了患者的生命,提高了患者的生活质量,但其治疗针对性不强,不能有效清除体内特定部位的HIV病毒。为此,人们采用多种技术手段,制备各种形式的抗艾滋病药物递送载体,如纳米粒、脂质体、树状大分子等,希望针对不同细胞和解剖学的病原体库进行靶向药物递送。本文对近年来有关抗艾滋病药物靶向制剂研究的进展做一综述。

Anti-AIDS drugs targeting drug delivery systems:research advances

The discovery and utilization of anti-AIDS drugs therapy have not only increased lifespan,but also enhanced the quality of life of HIV infected people.However,limitations of currently available drug regimens and dosage forms often fail to effectively reduce the HIV viral load in the viral reservoirs in vivo.To overcome the drawbacks of present anti-AIDS drugs′ dosage forms,engineered nanocarriers including polymeric nanoparticles,liposomes,solid lipid nanoparticles and dendrimers are developed to facilitate these drugs targeting to the HIV viral reservoirs.This article reviews recent advances in the field of targeting drug delivery systems for the treatment of AIDS.