活性维生素D3改善骨质疏松状态下钛种植体的稳定性

目的：观察活性维生素D，（VitD，）对骨质疏松症大鼠体内钛种植体早期稳定性的影响。方法：对20只雌性SD大鼠行卵巢切除术，术后12周于大鼠胫骨干骺端植入纯钛种植体，左右各1枚；术后所有实验动物被随机分为两组，对照组和实验组各10只。术后第1天起，实验组大鼠按0．1P,g／妇／d喂食VitD，，对照组给予赋形剂。8周后处死动物，收集含有钛钉的胫骨，分别行Micro—CT、组织学及生物力学分析。结果：Micro—CT、组织学及生物力学检测结果显示，与对照组相比，实验组骨结合率（％OI）、相对骨面积（BA）、骨与种植体的接触率（BIC）、最大推出力均显著增加（P〈0．01）。结论：VitD，可以提高骨质疏松症大鼠体内种植体的早期稳定性。

Activated vitamin D3 improves titanium implant stability in the osteoporotic rats.

Objective：To investigate the effect of 1,25 （OH）2D3 on implant early stability in osteoporotic rats. Method： Bilateral ovariectomy was performed in twenty Sparague-Dawley rats. Twelve weeks after surgery, titanium screws were placed into the proximal tibiae of rats. Each rat had 2 screws. All animals were randomly divided into two groups： con- trol （10 rats） and experimental （10 rats）. The experimental group was fed a vitamin D diet at 0.1 μg / kg / d, and control group received vehicle. All animals remained on their previous diet until sacrifice at eight weeks. Micro-CT, histologic and biomechanical analysis were performed. Result：The results of Micro-CT analysis,histomorphometry, and biomechanical test showed that,percent osseointegration, bone area density,bone-to-implant contact, and the maximal push-out force all increased obviously in the experimental group than that in control. Conclusion： 1,25 （OH）2D3 can improves implant early stability in osteoporotic rats.