| 2—（1H）—喹啉酮类化合物的合成及降压活性 |
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| 引用本文： | 冉崇昭,夏霖,倪沛洲.2—（1H）—喹啉酮类化合物的合成及降压活性[J].中国药科大学学报,2000,31(4):8-12. |
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| 作者姓名： | 冉崇昭 夏霖 倪沛洲 |
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| 作者单位： | [1]中国药科大学药物化学教研室 [2]中国药科大学生理学教研室 |
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| 摘 要： | 设计并合成了１０个含２（１Ｈ）－喹啉酮结构的ＤＤＰＨ类似物，其结构均经红上光谱、氢核磁共振谱、元素分析、质谱或高分辩质谱确证。改进了关键中间体４－省甲基－２（１Ｈ）－喹啉酮的制备。所有的化合物均进行了动物急性降压试验，一些化合物显示出良好的降压活性。
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| 关 键 词： | 喹啉酮类化合物 合成 降压活性 DDH类似物 |
| 修稿时间： | 2000-04-13 |
Synthesis and Bio-activity Study of the 2(1H)-Quinolone Compounds |
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| RAN Chong-Zhao,XIA Lin,NI Pei-Zhou,FU Ji-Hua.Synthesis and Bio-activity Study of the 2(1H)-Quinolone Compounds[J].Journal of China Pharmaceutical University,2000,31(4):8-12. |
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| Authors: | RAN Chong-Zhao XIA Lin NI Pei-Zhou FU Ji-Hua |
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| Institution: | RAN Chong-Zhao
,XIA Lin
,NI Pei-Zhou
,FU Ji-Hua
(Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009) |
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| Abstract: | Ten analogs of DDPH, which contain 2(1H) quinolone moiety, were synthesized and their structures were confirmed by IR, elemental analysis, \ 1H NMR and mass spectrum. The reported procedure for synthesis of key intermediate 4 bromomethyl 2(1H) quinolone was improved. All of these compounds were tested for their antihypertensive activities in rat and two compounds showed considerable antihypertensive activities. |
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| Keywords: | DDPH Analogues 2(1H)-Quinolone Antihypertensive activity |
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