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| 尼莫地平缓释片制备 | |
| 引用本文： | 张辉. 尼莫地平缓释片制备[J]. 齐鲁药事, 2008, 27(3): 170-171 |
| 作者姓名： | 张辉 |
| 作者单位： | 山东省立医院,山东,济南,250021 |
| 摘 要： | 目的尼莫地平缓释片制备。方法通过比较体外释放度筛选处方。将尼莫地平微粉化与羟丙甲纤维素等混合,湿法制粒后制备缓释片,测定其释药度。结果羟丙甲纤维素、乳糖等对释放度均有影响。结论试制的与已经上市的尼莫地平缓释片释放行为基本一致。 |
| 关 键 词： | 尼莫地平 缓释片 释放度 |
| 文章编号： | 1672-7738(2008)03-0170-02 |
Formulation and evaluation of sustained-release tablets of nimodipine |
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| ZHANG Hui. Formulation and evaluation of sustained-release tablets of nimodipine[J]. qilu pharmaceutical affairs, 2008, 27(3): 170-171 | |
| Authors: | ZHANG Hui |
| Abstract: | OBJECTIVE To prepare nimodipine sustained-release tablets.METHODS An optimum formulation was screened by comparing release characteristics.RESULTS The dissolution rate is decreased as hydroxypropylmethylcellulose(HPMC) increasing;Lactose and dextrin is good for preparing nimodipine sustained-release tablets;CONCLUSION No great difference in dissolution behavior is observed between market nimodipine sustained-release tablets and trial-products. |
| Keywords: | Nimodipine sustained-release tablet dissolution rate |
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