昂丹司琼和氟哌利多及甲氧氯普胺联合预防妇科肿瘤患者术后恶心呕吐的效果

目的比较昂丹司琼、氟哌利多、甲氧氯普胺单用或合用在预防妇科肿瘤患者术后恶心呕吐(PONV)的效果。方法将160例妇科肿瘤患者随机分为4组,A组在发生PONV后给予昂丹司琼8mg,B组术后给予昂丹司琼8mg,C组术后给予氟哌利5mg 甲氧氯普胺20mg,D组先给予昂丹司琼8mg后给予氟哌利多5mg 甲氧氯普胺20mg,比较4组患者术后48h内PONV总发生率。结果4组患者术后48h内PONV总发生率分别为52.5%、25.0%、27.5%、7.5%;D组术后48h内PONV总发生率与A组、B组和C组间差异均有统计学意义(P<0.05)。结论甲氧氯普胺、昂丹司琼、氟哌利多联合应用预防妇科肿瘤患者硬膜外术后镇痛时PONV较单用或两种药物联用效果好。

A Comparative Study of Ondansetron and Droperidol and Metoclopramide in Prevention of Postoperative Nausea and Vomiting of Patients with Gynecology Tumors

Objective To compare the effects of Ondansetron,Droperidol and Metoclopramide used alone or in combination in prevention of postoperative nausea and vomiting(PONV)of patients with gynecology tumors.Methods Totally 160 patients with gynecology tumors were divided randomly into four groups:the patients in group A were given Ondansetron 8 mg after occurrence of PONV,the patients in group B were given Ondansetron 8 mg after operation,the patients in group C were given Droperidol 5 mg plus Metoclopramide 20 mg,the patients in group D were first given Ondansetron 8 mg and then Droperidol 5 mg plus Metoclopramide 20 mg.the total incidences of PONV 48 h after operation in the four groups were compared.Results The incidences of PONV in 4 groups within 48h of postoperation were 52.5% in group A;25.0%2 in group B;27.5% in group C and 7.5% in group D,the effect of prevention in group D was best,as compared with other three groups(P<0.05).Conclusion The effect of combined administration of Ondansetron,Droperidol and Metoclopramide in prevention of postoperative nausea and vomiting by epidural analgesia of postoperation is better than any single one or combination of any two.