| 5-羟色胺受体与肠易激综合征 |
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| 引用本文： | 林懋惺,杨丽. 5-羟色胺受体与肠易激综合征[J]. 医学综述, 2007, 13(5): 398-400 |
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| 作者姓名： | 林懋惺 杨丽 |
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| 作者单位： | 四川大学华西医院消化科,成都,610041 |
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| 摘 要： | 目前认为胃肠动力异常和内脏感知障碍、胃肠分泌异常是肠易激综合征(IBS)产生的主要的病理生理机制。大量的动物实验和临床试验已证实5-羟色胺(5-HT)及其受体参与IBS的病理生理机制,并发挥重要的作用。随着对其研究的深入,使用5-HT受体调节剂治疗IBS已成为热点。本文简要综述5-HT受体及其特异性调节剂在IBS中的作用机制及临床疗效。
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| 关 键 词： | 肠易激综合征 5-羟色胺受体 5-羟色胺受体拮抗剂 5-羟色胺受体激动剂 |
| 文章编号： | 1006-2084（2007）05-0398-03 |
| 收稿时间： | 2006-06-01 |
| 修稿时间： | 2007-01-25 |
5-hydroxytryptamine Receptors and Irritable Bowel Syndrome |
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| LIN Mao-xing,YANG Li. 5-hydroxytryptamine Receptors and Irritable Bowel Syndrome[J]. Medical Recapitulate, 2007, 13(5): 398-400 |
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| Authors: | LIN Mao-xing YANG Li |
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| Affiliation: | Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu 610041, China |
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| Abstract: | The main pathophysiological mechanisms of irritable bowel syndrome (IBS) are abnormal stomach intestine mobility,disturbance of internal organ perception and parasecretion of stamach intestine.A growing body of evidence from the animal experiments and clinical trials suggest that 5-hydroxytryptamine (5-HT) and its specific receptors play a key role in the pathophysiological mechanism of IBS.With the further study,it is becoming a hot spot to apply its receptor regulation agents to treat IBS.This article reviews 5-HT receptor and its specific regulator about its action of mechanism and clinical effect in IBS. |
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| Keywords: | Irritable bowel syndrome 5-hydroxytryptamine receptor 5-hydroxytryptamine receptor antagonist 5-hydroxytryptamine receptor agonist |
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