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| 表皮生长因子受体对哮喘小鼠气道重塑的影响及机制 | |
| 引用本文： | 李晓辉,栾斌. 表皮生长因子受体对哮喘小鼠气道重塑的影响及机制[J]. 中国当代儿科杂志, 2010, 12(2): 137-140 |
| 作者姓名： | 李晓辉 栾斌 |
| 作者单位： | 李晓辉，栾斌 |
| 摘 要： | 目的：探讨哮喘小鼠气道重塑与表皮生长因子受体（EGFR）、肝素结合性表皮生长因子（HB-EGF）的关系以及EGFR酪氨酸激酶抑制剂（AG1478）对气道重塑的干预作用。方法：建立哮喘小鼠气道重塑模型，对肺组织切片行Masson和过碘酸雪夫（PAS）染色分别显示胶原沉积和气道黏膜杯状细胞增生情况。应用免疫组化和RT-PCR方法分别检测HB-EGF的蛋白和EGFR、HB-EGF mRNA表达的变化。结果：哮喘组出现气道重塑的特征性改变，HB-EGF、EGFR表达水平增高。AG1478干预组较哮喘组气道重塑有所改善，EGFR、HB-EGF表达降低（P<0.05）。结论：EGFR参与哮喘小鼠气道重塑，其酪氨酸激酶抑制剂AG1478可缓解气道重塑过程。AG1478可能通过下调EGFR及HB-EGF的表达以及抑制依赖于EGFR下游的细胞信号转导级联反应来缓解哮喘气道重塑过程。［中国当代儿科杂志，2010，12（2）：137-140］ |
| 关 键 词： | 表皮生长因子受体 肝素结合性表皮生长因子 哮喘 气道重塑 小鼠 |
Effect of epidermal growth factor receptor on airway remodeling in asthmatic mice and its mechanism |
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| LI Xiao-Hui,LUAN Bin. Effect of epidermal growth factor receptor on airway remodeling in asthmatic mice and its mechanism[J]. Chinese journal of contemporary pediatrics, 2010, 12(2): 137-140 | |
| Authors: | LI Xiao-Hui LUAN Bin |
| Affiliation: | LI Xiao-Hui, LUAN Bin |
| Abstract: | Objective To explore the relationship of airway remodeling with epidermal growth factor receptor (EGFR) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) levels in asthmatic mice and the effect of EGFR tyrosine kinase inhibitor (AG1478) on airway remodeling.Methods Twenty-four male BALB/c mice were randomly divided into three groups:normal control,asthma,AG1478-treated. Mice were sensitized and challenged with ovalbumin (OVA) and a mouse mode1 of asthma was prepared. Collagen depositio... |
| Keywords: | Epidermal growth factor receptor Heparin-binding epidermal growth factor-like growth factor Asthma Airway remodeling Mice |
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