| 戊型肝炎病毒核酸阳性血浆经输血传播感染恒河猴的研究 |
| |
| 引用本文： | 夏宁邵,张军,郑英杰,邱艳,葛胜祥,叶祥忠,欧山海.戊型肝炎病毒核酸阳性血浆经输血传播感染恒河猴的研究[J].中华肝脏病杂志,2004,12(1):13-15. |
| |
| 作者姓名： | 夏宁邵 张军 郑英杰 邱艳 葛胜祥 叶祥忠 欧山海 |
| |
| 作者单位： | 1. 361005,厦门,厦门大学细胞生物学与肿瘤细胞工程教育部重点实验室,福建省医学分子病毒学研究中心
2. 北京市红十字血液中心 |
| |
| 摘 要： | 目的了解戊型肝炎病毒(HEV)核酸阳性血浆对灵长类动物的感染性和致病性。方法对抗-HEV IgM阳性而IgG阴性志愿献血员血浆进行HEV RNA检测，并将存在病毒血症献血员的10ml血浆静脉输入健康恒河猴，观察其对恒河猴的感染性和致病性。结果从1份抗-HEV IgM阳性而IgG阴性志愿献血员血浆中分离出HEV基因IV型RNA片段。该份血浆输入恒河猴后，恒河猴出现典型急性肝炎生物化学和病理表现，病毒血症，血清抗-HEV IgM和IgG抗体阳转。结论HEV病毒血癌献血员血浆输入可以引起灵长类动物的HEV感染以及急性肝炎，提示HEV经输血传播的可能性。
|
| 关 键 词： | 戊型肝炎病毒 核酸阳性 血浆 输血传播 恒河猴 HEV 抗体 |
| 修稿时间： | 2003年10月16 |
Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey |
| |
| XIA Ning-shao,ZHANG
Jun,ZHENG Ying-jie,QIU Fan,GE Sheng-xiang,YE Xiang-zhong,OU Shan-hai.Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey[J].Chinese Journal of Hepatology,2004,12(1):13-15. |
| |
| Authors: | XIA Ning-shao ZHANG
Jun ZHENG Ying-jie QIU Fan GE Sheng-xiang YE Xiang-zhong OU Shan-hai |
| |
| Institution: | The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China. |
| |
| Abstract: | Objective To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals. Methods RNA fragment of HEV genotype IV was detected on one donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity. Results Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data. Conclusion Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E. |
| |
| Keywords: | Hepatitis E virus Monkeys Transfusion transmission |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
