来曲唑配合中药治疗多囊卵巢综合征排卵障碍的疗效观察

目的:观察来曲唑配合中药治疗多囊卵巢综合征(PCOS)所致排卵障碍的临床效果及安全性。方法:选取门诊PCOS患者300例,随机分为3组:枸橼酸氯米芬(CC)组100例(188周期)、尿促性腺激素(HMG)组100例(104周期)、来曲唑(LE)组100例(155周期)。比较3组治疗后成熟卵泡出现率、排卵率、妊娠率、流产率、多胎畸胎率、取消周期数、无优势卵泡发生数、发生卵巢过度刺激综合征(OHSS)等参数。结果:CC组出生30人,HMG组出生34人,LE组出生43人;在成熟卵泡出现率、排卵率、妊娠率方面,LE组高于CC组、HMG组(P<0.05),HMG组高于CC组(P<0.05);在流产率、畸胎率、取消周期数、无优势卵泡发育数、OHSS方面,LE组低于CC组、HMG组(P<0.05),CC组、HMG组比较差异无统计学意义(P>0.05);多胎率HMG组高于CC组、LE组(P<0.05)。结论:应用来曲唑配合中药可治疗PCOS排卵障碍引起的不孕,排卵率及妊娠率较高,经济、方便、安全。

Curative Efficacy of Letrozole Combined with Traditional Chinese Medicine for Ovulation Dysfunction Caused by Polycystic Ovarian Syndrome

OBJECTIVE： To evaluate the clinical efficacy and safety of letrozole combined with traditional Chinese medicine for ovulation dysfunction induced by polycystic ovarian syndrome（PCOS） . METHODS： 300 PCOS outpatients were randomized to 3 groups of 100 each： elomipbene citrate （CC） group （188 cycles）; urinary gonadotropin （HMG） group （104 cycles） and letrozole （LE） group （155 cycles）. The occurrence rate of mature follicle, ovulation rate, pregnancy rate, abortion rate, superfoetation - terata rate, cancellation rate, incidence of no dominant follicle forming and OHSS etc were compared between the two groups after treatment. RESULTS： 30 babies were born in CC group, 34 in HMG group and 43 in LE group were born. The occurrence rate of mature follicles, ovulation rate and pregnancy rate in the LE group were higher than in either CC group or HMG group（P〈0.05）, and which were higher in HMG group than in CC group（P〈0.05）; the abortion rate, terata rate, cancellation rate of menstruation cycles, incidence of no dominant follicle forming and OHSS were higher in LE group than in CC group or HMG group（P 〈 0.05）, but the differences between CC group and HMG group were not significant（P 〉 0.05）; the superfoetation rate in HMG group was higher than in CC group or LE group（P〈0.05） . CONCLUSION： Letrozole combined with Chinese medicine can improve the ovulation rate and pregnancy rate in the treatment of infertility induced by ovulation failure in patients with PCOS; furthermore, it is economic, convenient and safe to use.