| 复方利多卡因乳膏的处方优选 |
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| 引用本文： | 盛国荣. 复方利多卡因乳膏的处方优选[J]. 中国药房, 2009, 0(28): 2182-2184 |
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| 作者姓名： | 盛国荣 |
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| 作者单位： | 江苏省南通市皮肤病性病防治所,南通市226006 |
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| 基金项目： | 南通市指令性社会发展科技计划项目（S2007026） |
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| 摘 要： | 目的:优选复方利多卡因乳膏处方。方法:采用正交试验设计法进行处方中各成分的用量筛选,以镇痛实验的小鼠痛阈提高百分率和抗炎实验的小鼠耳肿胀抑制率为考察指标,确定乳膏的最佳处方并进行验证试验。结果:优选的复方利多卡因乳膏的最佳处方为1000g乳膏中含盐酸利多卡因20g、马来酸氯苯那敏5g、薄荷脑20g、莫匹罗星20g;验证试验中小鼠痛阈提高百分率和耳肿胀抑制率均>60%,考察指标结果达到要求。结论:优选的复方利多卡因乳膏处方合理,可为临床应用提供实验依据。
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| 关 键 词： | 复方利多卡因乳膏 正交设计 处方优选 小鼠 镇痛、抗炎实验 |
Optimization of Formula of Compound Xylocaine Cream |
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| SHENG Guo-rong. Optimization of Formula of Compound Xylocaine Cream[J]. China Pharmacy, 2009, 0(28): 2182-2184 |
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| Authors: | SHENG Guo-rong |
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| Affiliation: | SHENG Guo-rong(Jiangsu Nantong Prophylactico - therapeutic Institution for Dermatosis and Venereal Diseases, Nantong 226006, China) |
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| Abstract: | OBJECTIVE： To optimize the formula of employed to optimize the amount of each component in the compound xylocaine cream. METHODS： Orthogonal design was formula of compound xyloeaine cream, and the pain threshold iraprovement rate in pain- relieving experiment of mice and the mice ear edema inhibition rate in the anti - inflammatory experiment served as indexes to optimize the formula, meanwhile a verification test was conducted. RESULTS： The optimized formula was as follows： xylocaine 20 g, chlorphenamine maleate 5 g, menthol 20 g, mupirocin 20 g in every 1 000 g cream. Both the pain threshold improvement rate and the ear edema inhibition rate in mice were all higher than 60%, which were up to the standard. CONCLUSION： The formula for compound xylocaine cream is reasonable, and this study provids experimental basis for clinical application of compound xylocaine cream. |
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| Keywords: | Compound xylocaine cream Orthogonal design Formula optimization Mice Painrelieving and antiin-flammatory experiment |
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