益气养阴药膳对早期糖尿病肾病疗效的影响

[目的]观察益气养阴药膳对早期糖尿病肾病的治疗作用和临床疗效。[方法]将80例早期糖尿病肾病属中医气阴两虚患者分为益气养阴药膳治疗组(简称药膳组)和普通治疗对照组(简称对照组)各40例。两组患者的饮食控制方法相同,均给予糖适平降糖治疗,降压和降脂等基础治疗也一致。40例药膳组病人同时给予益气养阴药膳(药膳方一:山药山楂花粉肉饼:山药粉30 g、焦山楂30g、天花粉30 g、瘦肉50 g;药膳方二:太子参黄芪生地丹参鸡羹:太子参20 g、黄芪30g、生地30g、丹参30g、鸡肉丝80 g)治疗。治疗前后观察症状改善情况、尿蛋白和尿糖、血糖、微量蛋白及尿肌酐、血脂及肾功能变化。[结果]除对血糖改善两组作用相仿(P>0.05)外,药膳组对症状改善、血尿常规、微量蛋白及尿肌酐的变化、血脂及肾功能的作用均优于对照组(P<0.05或P<0.01)。两组总疗效比较,药膳组显效15例(37.5%),有效21例(52.5%),无效4例(10.0%),总有效率为90.0%;对照组显效9例(22.5%),有效19例(47.5%),无效12例(30.0%),总有效率为70.0%。经Ridit分析,治疗组的疗效优于对照组(P<0.05)。[结论]益气养阴药膳对提高早期糖尿病肾病疗效作用确切,且服用方便、无副作用,值得推广。

Therapeutic Effect of Qi-reinforcing and Yin-nourishing Medicated Diet for Early Diabetic Nephropathy

[Objective] To observe the therapeutic effect of Qi-reinforcing and yin-nourishing medicated diet for early diabetic nephropathy (EDN). [Methods] Eighty cases of EDN were allocated to 2 groups. Groups A and B (40 in each group) were both treated with low-sugar and low-fat diet, glurenorm for decreasing blood sugar, and drugs for decreasing blood pressure and blood lipid. Additionally, group A received Qi-reinforcing and yin-nourishing medicated diet. Symptoms, urinary protein, urinary sugar, blood glucose, microglobulin (MG), urinary creatinine, blood lipid and renal function were observed before and after treatment. [Results] Groups A and B had the similar effect in decreasing blood glucose content ( P > 0.05). The effect of group A was better than that of group B in relieving symptoms and improving routine blood and urine examination indexes, MG and urinary creatinine levels, blood lipid content and renal function (P < 0.05 or P < 0.01). In group A, 15 (37.5%) were markedly effective, 21 (52.5%) effective, 4 (10.0%) ineffective and the total effective rate was 90.0%; in group B, 9 (22.5%) were markedly effective, 19 (47.5%) effective, 12 (30.0%) ineffective and the total effective rate was 70.0%. Ridit analysis showed that the therapeutic effect in group A was better than that in group B (P < 0.05). [Conclusion] Qi-reinforcing and yin-nourishing medicated diet has a synergistic action for the treatment of EDN and has no side effects.