Effects of various drugs on the bronchoconstriction produced by transmural stimulation of the perfused guinea pig lung |
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| Authors: | F P Luduena P A Fisher |
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| Affiliation: | 1. Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA;2. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA;1. Division of Allergy Immunology, Department of Medicine, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, United States;2. Division of Pediatric, Department of Emergency Medicine, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, United States;3. Adult Emergency Medicine, Department of Emergency Medicine, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, United States;1. Global Clinical Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland;2. Genentech Inc., CA, USA;3. Mount Vernon Cancer Centre, London, UK;4. Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas, MD Anderson Cancer Center, TX, USA;5. Oncology Biomarker Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland;6. Aix-Marseille University, Assistance Publique-Hopitaux de Marseille, Centre Hospitalo-Universitaire Timone, Service de Neuro-Oncologie, Marseille, France |
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| Abstract: | ![]()
Acetylcholine (ACh), oxotremorine, pilocarpine, nicotine, histamine and serotonin produced bronchoconstriction in the perfused guinea pig lung.Atropine blocked the effect of oxotremorine and pilocarpine, reduced the effect of acetylcholine, reduced that of nicotine and did not alter serotonin or histamine broncoconstriction. Nicotine bronchoconstriction and the residual effect of ACh on the atropinized lung were abolished by hexamethonium. Transmural stimulation of the lung produced bronchoconstriction, potentiated by eserine; atropine abolished this potentiation. On the atropinized lung hemicholinium-3 in some cases reduced, in others it failed to reduce, the effects of repeated transmural stimulations. Atropine alone (up to 4 × 10−5) or together (10−6) with cyproheptadine and hexamethonium had only a minor effect on the electrically induced bronchoconstriction. It is concluded that the atropine-resistant bronchoconstrictor effect is mediated by autonomic postganglionic fibers that do not release acetylcholine, histamine or serotonin. |
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