2%美开朗与0.5%噻吗心安滴眼液治疗开角型青光眼与高眼压症的临床对照研究

目的以噻吗心安滴眼液作对照,在原发性开角型青光眼和高眼压症患者中评价美开朗滴眼液的降眼压、内在拟交感活性作用。方法选择开角型青光眼和高眼压症患者50例50眼,随机分为美开朗组和噻吗心安组2组,各25例25眼。美开朗组滴用2%美开朗眼液,噻吗心安组滴用0.5%噻吗心安眼液,一日2次,共12周,比较两种滴眼液的降眼压作用及局部和全身副作用。结果两组患者用药后眼压均下降,与用药前相比均有显著性差异(P<0.01)。两组间眼压下降值无显著性差异(P>0.05)。用药12周,美开朗组心率平均降低3.6次,噻吗心安组心率平均降低6.5次,两者相比有显著性差异。结论美开朗滴眼液对开角型青光眼和高眼压症患者具有明显的降眼压作用,和噻吗心安滴眼液局部降眼压作用相同,但对心率的抑制作用比噻吗心安小。

Comparison of 2% carteolol and 0.5% timolol in patients with primary open angle glaucoma and ocular hypertension

Objective To compare the efficacy for intraocular pressure(IOP) reduction and the intrinsic sympathomimetic activity (ISA) of 2% carteolol with 0.5% timolol in patients with primary open angle glaucoma and ocular hypertension. Methods 50 patients (50 eyes) with primary open angle glaucoma or ocular hypertension were randomized, 25 (25 eyes) to cartelol, another 25 (25 eyes) to timolol. The patients received either 2% cartelol or 0.5% timolol eye drops twice daily for a period of 12 weeks. IOP reduction and side effects of 2% cartelol and 0.5% timolol eye drops were compared. Results The two preparations significantly lowed IOP throughout the study(P<0.01),with no significant differences being observed (P>0.05). At the 12th week, 2% cartelol and 0.5% timolol reduced mean heart rates by 3.6 beats per minute and 6.5 beats per minute respectively. There were significant differences between the two preparations (P<0.05). Conclusion 2% cartelol has an obvious efficacy for IOP reduction with primary open angle glaucoma and ocular hypertension. 2% cartelol and 0.5% timolol have the same effect on IOP reduction, but 2% cartelol has less repression of the heart rate than 0.5% timolol.