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| 高效硝苯啶舌下片的研究 | |
| 引用本文： | 吴志明 林连观. 高效硝苯啶舌下片的研究[J]. 中国医药工业杂志, 1992, 23(7): 304-307 |
| 作者姓名： | 吴志明 林连观 |
| 作者单位： | 上海医药工业研究院 上海200437(吴志明，王雅珍，侯惠民)，空军杭州医院 杭州310004(林连观，吕爱华) |
| 摘 要： | 采用固体分散技术,将硝苯啶制成舌下片。体外溶出、粘膜渗透试验及家兔给药后的血药浓度测定等证明,本片体外溶出快,粘膜透过量大,生物利用度高。 |
| 关 键 词： | 硝苯啶 固体分散物 舌下片 |
NIFEDIPINE SUBLINGUAL TABLETS WITH HIGH BIOAVAILABILITY |
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| WU Zhi-Ming WANG Ya-Zhen LIN Lian-Guana L. NIFEDIPINE SUBLINGUAL TABLETS WITH HIGH BIOAVAILABILITY[J]. , 1992, 23(7): 304-307 | |
| Authors: | WU Zhi-Ming WANG Ya-Zhen LIN Lian-Guana L |
| Affiliation: | WU Zhi-Ming WANG Ya-Zhen LIN Lian-Guan~a L |
| Abstract: | Nifedipine is a poorly water-soluble drug and possesses lowbioavailability when administered orally.In order to improve the bioavailabilityof its tablets,with the solid dispersion of nifedipine and PVP with 1:2 weight ratio,the sublingual tablets were prepared.In vitro,nifedipine was released from thetablets more rapidly than the conventional tablets,and in vivo study showed thatthe tablets had higher bioavailability. |
| Keywords: | nifedipine solid dispersion sublingual tablet bioavaflability PVP mucosa |
| 本文献已被 CNKI 维普 等数据库收录！ | |