普米克令舒和博利康尼雾化吸入治疗小儿哮喘的疗效

目的:探讨普米克令舒和博利康尼雾化吸入治疗小儿哮喘的临床疗效。方法:将我院收治的小儿哮喘的病例64例随机分为研究组和对照组,每组32例。研究组患儿给予普米克令舒1～2mL(含布地奈德0.5～1mg)、博利康尼1～2mL(含博利康尼0.25～0.5mg),加入生理盐水2～3mL,雾化吸入,2～3次/d,每次10～15min;对照组患儿给予氨茶碱4～5mg/kg,氢化考的松5～10mg/kg,静脉滴注,1次/d,疗程5～7d。观察两组患儿临床表现及疗效。结果:研究组患儿治疗后咳喘、哮鸣音、湿啰音等恢复正常时间较对照组短(P<0.05);研究组临床疗效显著好于对照组(P<0.05)。治疗过程中两组患儿无明显不良反应,两组患儿呼吸频率变化差异无统计学意义(P>0.05),对照组患儿心率增快,与研究组差异有统计学意义(P<0.05)。结论:普米克令舒和博利康尼雾化吸入治疗小儿哮喘疗效显著,且不良反应较低,操作简便,可作为治疗小儿哮喘的主要方法。

The efficacy of budesonide and terbutaline inhalation on child asthma

Objective: To investigate the efficacy of budesonide and terbutaline inhalation for child asthma.Methods: A total of 64 pediatric cases of asthma were randomly divided into study group and control group with 32 cases in each group.Budesonide(1 ~ 2 mL,including budesonide 0.5 ~ 1 mg),and terbutaline(1 ~ 2 mL,including terbutaline 0.25 ~ 0.5mg) were added to normal saline(2 ~ 3 mL) and was given to the treatment group for inhalation after atomization,10 ~ 15 min per time and 2 ~ 3 times per day.The control group was given aminophylline(4~5mg/kg) and hydrocortisone(5 ~ 10mg/kg) for intravenous drip,once per day for 5 ~ 7d.Clinical efficacy and symptoms of the two groups were observed and compared.Results: The treatment group showed significant shorter recovery time than the control group regarding to symptoms of coughing,wheezing,crackles(P<0.05);It also showed better clinical efficacy than the control group(P<0.05).No obvious adverse reactions were observed in both groups(P> 0.05).There’s no significant difference in changes of breathing frequency between the two groups(P>0.05) but significant difference in the increase of heart rate were observed(P<0.05).Conclusions:Budesonide combing with terbutaline for inhalation after atomization is effective on child asthma with advantages of easy manipulation and low incidence of side effects.