不同术式治疗早期非小细胞肺癌的临床疗效

目的：比较电视辅助胸腔镜手术（VATS）及传统开胸手术（TOS）治疗早期非小细胞肺癌的临床疗效。方法：收集2006年1月-2009年6月期间行VATS治疗非小细胞肺癌患者28例（VATS组）及同期行TOS治疗非小细胞肺癌患者25例（TOS组），比较两组在手术时间、术中出血量、术后疼痛及胸管引流时间、住院时间、1年后复发、转移、死亡率的差异。结果：VATS组手术时间、胸管引流时间及引流量较TOS组无明显差异（P〉0．05）；与TOS组相比，VATS组术后疼痛明显减轻、围手术期出血量明显减少，术后住院时间明显低于TOS组（P〈0．05）。术后1年两组间复发转移率及死亡率无差异（P〉0．05）。结论：全胸腔镜下肺叶切除具有创伤小疼痛小、术后恢复快等优点，是治疗早期非小细胞肺癌较好的方法。

Effectiveness of different surgical approaches for early-stage non-small cell lung carcinoma

Objective：To compare the effectiveness of video-assisted thoracoscopic surgery （VATS） and standard thoracotomy （TOS） for early-stage non-small cell lung carcinoma. Methods： We enrolled 28 patients with early-stage non-small cell lung carcinoma treated by VATS （VATS group） and 25 patients treated by TOS （TOS group） between January 2006 and June 2009. Distinctions in postoperative conditions, including the duration of surgery, volume of hemorrhage, scale of pain, duration of thoracic catheter drainage, hospital stay, 1-year recurrence, metastasis and mortality were compared between 2 groups. Results： VATS group showed no evidence of significant difference （P 〉 0.05 ） in the duration of surgery as well as the duration and volume of thoracic catheter drainage as compared with that of TOS group. VATS group exhibited markedly lower scale of postoperative pain, perioperative hemorrhage and hospital stay （P 〈 0.05 ）. However, there was no significant difference （ P 〉 0.05 ） in 1-year post-operative rates of recurrence, metastasis and mortality between both groups. Conclusion ： VATS benefits from less injury, lower scale of pain and rapid recovery, thereby offering a promising approach for treatment of early-stage non-small cell lung carcinoma.