22号染色体与疾病

22号染色体是人类基因组计划实施以来最先完成序列测定的常染色体。序列分析揭示 ,2 2号染色体长臂含有 6 79个基因 ,包括 2 47个“已知基因” ,15 0个“相关基因” ,148个“预报基因”和 134个“假基因”。综合目前认识 ,与 2 2号染色体相关的疾病大致可分为 3类 :先天发育异常、肿瘤和某些疾病易感性。对该染色体DNA序列的测定不仅有助于人们了解其基因特性 ,还为探索有关疾病的发病机制并最终攻克疾病提供了重要信息

Human chromosome 22 and diseases

Chromosome 22 is the first sequenced human autosome since Human Genome Project was launched. Sequence analysis revealed that the long arm of human chromosome 22 contains 679 genes, in which 247 known genes, 150 relative genes, 148 predicted genes and 134 pseudogenes. As known so far, the diseases related with chromosome 22 can be generally divided into three groups: genetic developmental anomaly, tumor and susceptibility to certain diseases. The success of this important chromosome sequencing will not only help people understand the characteristics of its genes, but also provide important information to unravel the etiology of certain diseases and contribute to the final cure of them.