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| 鸟氨酸脱羧酶及其基因表达在脑胶质瘤研究中的进展 | |
| 引用本文： | 栗世方,周茂德,扈国杰,胡海燕. 鸟氨酸脱羧酶及其基因表达在脑胶质瘤研究中的进展[J]. 中华神经医学杂志, 2003, 2(6): 459-461 |
| 作者姓名： | 栗世方 周茂德 扈国杰 胡海燕 |
| 作者单位： | 1. 华北石油总医院神经外科,河北,任丘,062552 2. 山东大学齐鲁医院神经外科,山东,济南,250012 3. 山东大学医学院分子生物学教研室,山东,济南,250012 |
| 基金项目： | 山东省科技厅资助项目(973000061) |
| 摘 要： | 鸟氨酸脱羧酶(ODC)足多胺合成的关键酶，ODC活性的改变可作为反映脑胶质瘤恶性程度的可靠的生物学标志；ODC基凶的诱导与恶性肿瘤的发生及其浸润性密切相关，因而具备癌基因的特性。ODC抑制剂DFMO及针对ODC的抗酶蛋白(AZ)可能对脑胶质瘤有着潜在的治疗作用。 |
| 关 键 词： | 鸟氨酸脱羧酶 基因表达 脑胶质瘤 癌基因 0DC 肿瘤 |
| 文章编号： | 1671-8925(2003)06-459-03 |
| 修稿时间： | 2003-06-05 |
The research progress of ornithine decarboxylase and its gene expression in human glioma |
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| LI Shifang,ZHOU Maode,HU Guojie,HU Haiyan. The research progress of ornithine decarboxylase and its gene expression in human glioma[J]. Chinese Journal of Neuromedicine, 2003, 2(6): 459-461 | |
| Authors: | LI Shifang ZHOU Maode HU Guojie HU Haiyan |
| Affiliation: | LI Shifang,ZHOU Maode,HU Guojie,HU HaiyanDepartment of Neurosurgery,General Hospital of Huabei Oil Field,Renqiu 062552,China, Department of Neurosurgery,Qilu Hospital,Shandong University,Ji'nan 250012,China, Department of Molecular Biology,Medical College of Shandong University,Ji'nan 250012,China |
| Abstract: | Ornithine decarboxylase (ODC) is the first metabolic key enzyme of polyamine metabolism, and the activity of ODC represent biochemical markers of malignancy in glioma. The induction of ODC-gene is closely associated with tumor cell proliferation and invasion, so the ODC-gene has characteristics of oncogenes. Difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase and the antizyme (AZ)which targets ODC might have potential therapeutical effect for human glioma. |
| Keywords: | glioma ornithine decarboxylase gene expression oncogenes |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |