氟比洛芬酯与氯诺昔康用于膝关节微骨折术超前镇痛的效果对比

目的比较氟比洛芬酯与氯诺昔康用于膝关节微骨折术超前镇痛的临床效果。方法选取2013年1月~2016年1月收治的膝关节软骨损伤患者300例,均行关节镜引导下微骨折术,根据术前应用超前镇痛情况分为三组(各100例),A组采用氟比洛芬酯,B组采用氯诺昔康,C组为对照组未采取超前镇痛。回顾性分析患者的临床资料,比较三组患者术中疼痛视觉模拟评分(VAS评分)、术后VAS评分、术后额外口服非甾体类药物情况及患者对镇痛总体质量的评价。结果术中关节镜清理时三组患者VAS评分差异无统计学意义(P0.05),而微骨折术时A、B两组VAS评分均低于C组,差异有统计学意义(P0.05),A、B两组差异无统计学意义(P0.05)。A、B两组术后1、4、8及24h的VAS评分均低于C组,差异有统计学意义(P0.05)。A组术后1h及4h的VAS评分显著低于B组,差异有统计学意义(P0.05),其余时间点A、B两组VAS评分差异无统计学意义(P0.05)。A、B两组治疗优良率均高于C组,差异有统计学意义(P0.05),A、B两组差异无统计学意义(P0.05)。结论氟比洛芬酯与氯诺昔康用于膝关节微骨折术均有利于减轻患者术中及术后疼痛,安全可靠,但术后早期氟比洛芬酯的镇痛效果更佳。

Comparison of the effect of flurbiprofen and lornoxicam in preemptive analgesia of patients with articular cartilage injury

Objective To compare the application effect flurbiprofen and lornoxicam in preemptive analge-sia for patients with articular cartilage injury . Methods Three-hundred articular cartilage injury patients treated with arthroscope technique from Jan .2013 to Jan.2016 were selected.They were divided into three groups according to the way of preemptive analgesia with 100 patients in each group .Group A was given flurbiprofen;group B was giv-en lornoxicam;and group C was blank control group .The visual analogue scale (VAS),postoperative VAS,additional oral taking of NSAIDs and the overall quality of analgesia were compared among the three groups .Results There was no significant difference in VAS during arthroscopic debridement among the three groups (P>0.05);the VAS of group A and B was lower than that of group C during microfracture surgery (P<0.05) while there was no signifi-cant difference between group A and B (P>0.05) .The VAS of group A and B was lower than that of group C at 1h,4h,8h and 24h after the surgery(P<0.05);the VAS of group A was lower than that of group B at 1h and 4h af-ter the surgery(P<0.05).The excellent and good rate of group A and B was higher than that of group C (P<0.05) and there was no significant difference in excellent and good rate between group A and B ( P >0.05). Conclusion For patients with articular cartilage injury ,using flurbiprofen and lornoxicam for preemptive analgesia can relieve pain in arthroscope treatment of microfracture and the former is better in the early time of postoperative analgesia .