人脑胶质瘤手术加局部热化疗研究

目的　探讨脑胶质瘤手术加局部热化疗的可行性和安全性。方法　回顾性分析脑胶质瘤手术加术中、术后间断热化疗等综合治疗 2 4例患者 (综合组 )的资料 ,与同期手术治疗的 46例未行热化疗的脑胶质瘤患者 (对照组 )进行比较。热化疗方法是术中用双极电凝直接加热瘤体残腔化疗药 ,43～ 44℃ ,持续2 5min。术后第 2天始 ,隔日将化疗药注射入埋置于头皮下的Ommaya药囊中 ,并用微波辐射加温 45min ,共 9次。结果　综合组平均生存 3 0 .75个月 ,对照组平均生存 8.85个月 ,综合组较对照组生存年限延长 (P <0 .0 0 1) ,而并发症并未增加。结论　脑胶质瘤术中和术后间断局部热化疗可提高手术疗效 ,减少肿瘤复发 ;微波辅助术后局部化疗药液加温是安全可行的

A study on the therapeutic effect of thermochemotherapy for patients with glioma

Objective To investigate the applicability and safety of localized thermochemotherapy during and after the surgery for patients with gliomas. Methods Retrospective analysis of the data of 24 patients with gliomas treated by use of heated antineoplastic agents during and after the surgery was conducted, and the therapeutic effect was compared with that of 46 patients treated with traditional surgery. Results The survival time of patients in thermochemotherapy group was obviously prolonged than that of the control group( 30.75 vs 8.85 months, P < 0.001 ). Conclusion Localized thermochemotherapy can be safely used during and after the surgery, and is effective for treatment of patients with glioma.