Fanconi anemia genes are highly expressed in primitive CD34+hematopoietic cells |
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| Authors: | Michel?Aubé,Matthieu?Lafrance,Isabelle?Brodeur,Marie-Chantal?Delisle,Madeleine?Carreau mailto:madeleine.carreau@crsfa.ulaval.ca" title=" madeleine.carreau@crsfa.ulaval.ca" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | 1.Unité de génétique humaine et moléculaire,CHUQ-H?pital St-Fran?ois d'Assise,Québec,Canada;2.Department of Pediatrics,Laval University,Québec,Canada |
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| Abstract: | ![]()
Background Fanconi anemia (FA) is a complex recessive genetic disease characterized by progressive bone marrow failure (BM) and a predisposition to cancer. We have previously shown using the Fancc mouse model that the progressive BM failure results from a hematopoietic stem cell defect suggesting that function of the FA genes may reside in primitive hematopoietic stem cells. |
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