| 以血管内皮生长因子及其受体为靶点的肿瘤血管生成抑制剂的研究进展 |
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| 引用本文： | 翟鑫,王玉亚,宫平.以血管内皮生长因子及其受体为靶点的肿瘤血管生成抑制剂的研究进展[J].中国药物化学杂志,2006,16(1):60-64. |
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| 作者姓名： | 翟鑫 王玉亚 宫平 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 肿瘤的生长和转移依赖于新生血管的形成,血管内皮生长因子(VEGF)在肿瘤新生血管形成中起关键作用。以VEGF及其受体为靶点,通过抑制肿瘤血管生长,从而遏制肿瘤的生长和转移的研究已经取得了一定的成果,在此对肿瘤血管生成抑制剂(TAI)的研究进展进行综述。
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| 关 键 词： | 药物化学 血管生成 综述 血管内皮生长因子 血管内皮生长因子受体 |
| 文章编号： | 1005-0108（2006）01-0060-05 |
| 收稿时间： | 2005-10-17 |
| 修稿时间： | 2005年10月17 |
Advance in tumor angiogenesis inhibitors targeting VEGF and its receptors |
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| ZHAI Xin,WANG Yu-ya,GONG Ping.Advance in tumor angiogenesis inhibitors targeting VEGF and its receptors[J].Chinese Journal of Medicinal Chemistry,2006,16(1):60-64. |
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| Authors: | ZHAI Xin WANG Yu-ya GONG Ping |
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| Institution: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical Uuniversity, Shenyang 110016, China |
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| Abstract: | Tumor growth and metastasis largely depend on angiogenesis and the vascular endothelial growth factor(VEGF) play a critical rule in tumor-associated angiogenesis.Targeting VEGF and its receptors,preventing the expansion of new blood vessel networks results in reduced tumor size and metastases.Some progress has been achieved in this field and recent developments of tumor angiogenesis inhibitors(TAI) targeting VEGF and its receptors were reviewed in this article. |
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| Keywords: | TAI |
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