ALT异常对HBsAg阳性孕妇妊娠过程与结局的影响

目的探讨孕期异常的ALT对HBsAg阳性的孕妇妊娠并发症及妊娠结局的影响。方法将327例HB-sAg阳性孕妇根据孕期ALT水平分为ALT正常组（n=251）和ALT异常组（n=76）,比较两组的妊娠期并发症和最终的妊娠结局。结果与ALT正常组比较,ALT异常组早产、胎儿窘迫和产后出血发生率明显升高（P均〈0.05）;ALT异常组低体重儿发生率高于ALT正常组（P〈0.05）;ALT异常组所分娩新生儿体质量、胎龄、出生后1 min Ap-gar评分均低于ALT正常组（P均〈0.01）。结论 HBsAg阳性的孕妇若妊娠期出现ALT异常,更易增加妊娠期并发症并影响妊娠结局。

Effect of elevated ALT on maternal-infant outcomes in pregnancy for hepatitis B virus carrier mothers

Objective To study the effect of elevated ALT on maternal-infant outcomes in pregnancy for mothers with hepatitis B surface antigen（HBsAg） seropositive.Methods A total of 327 HBsAg-positive mothers were divided into normal ALT group（n=251） and elevated ALT group（n=76） according to the serum levels of ALT during pregnancy.Pregnancy complications and outcomes were compared between two groups.Results The incidences of premature delivery,fetal distress,postpartum hemorrhage and low birth weigh of neonates in elevated ALT group were higher than those in normal ALT group（P〈0.05）.The average levels of birth weight,gestational age and Apgar score in neonates born to elevated ALT mothers were lower than those born to normal ALT group（P〈0.05）.Conclusion For mothers with HBsAg-positive,pregnancy with elevated ALT can increase the pregnancy complications and affect maternal-infant outcomes of pregnancy.