| Toll样受体2和Toll样受体4在HBV感染后的免疫作用 |
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| 引用本文： | 万彦彬,冷静. Toll样受体2和Toll样受体4在HBV感染后的免疫作用[J]. 国际免疫学杂志, 2009, 32(1): 51-54. DOI: 10.3760/cma.j.issn.1673-4394.2009.01.014 |
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| 作者姓名： | 万彦彬 冷静 |
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| 作者单位： | 广西医科大学微生物免疫教研室,南宁,530021;广西医科大学微生物免疫教研室,南宁,530021 |
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| 基金项目： | 广西科技厅青年自然科学基金 |
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| 摘 要： | Toll样受体（TLR）是启动固有免疫和调节适应性免疫的重要分子,参与肝脏对病毒及细菌的免疫TLR2、TLR4过程。在HBV的慢性化进程中,TLR2、TLR4与Thl和Th2的免疫平衡及调节性T细胞（Treg）的免疫抑制相关,HBV感染后,HBcAg刺激巨噬细胞产生TNF—α的作用需要TLR2参与,HBeAg的表达与否与TLR2的表达状态有关,而TLR4通过诱导iNOS的表达和激发HBV特异性免疫在体内抗HBV过程中起重要作用：
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| 关 键 词： | Toll样受体 乙型肝炎病毒 Th1或Th2 Toll样受体2 Toll样受体4 |
The immune role of TLR2 and TLR4 after HBV infection |
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| WAN Yan-bin,LENG Jing. The immune role of TLR2 and TLR4 after HBV infection[J]. International Journal of Immunology, 2009, 32(1): 51-54. DOI: 10.3760/cma.j.issn.1673-4394.2009.01.014 |
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| Authors: | WAN Yan-bin LENG Jing |
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| Affiliation: | (Departement of Microbiology and Immunology , Guangxi Medical Universty, Nanning 530021 , China) |
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| Abstract: | The Toll receptors(Toll-like receptors,TLRs) are important molecules which initiate natural immunity and regulate acquired immunity.Those molecules participate in the immunologic process of liver against bacteria and viruses.During the chronic process of HBV infection ,TLR2 and TLR4 are related to the balance between Th1 and Th2,and also related to Treg immunosuppression.The production of TNF-α after HBcAg stimulation requires the participation of TLR2.The expression of HBeAg is related to TLR2.TLR4 exert an important role in the process against HBV infection by inducing the expression of iNOS ,which stimulate HBV specifific immunity in vivo . |
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| Keywords: | Toll-like receptors HBV Th1/Th2 TLR2 TLR4 |
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