Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13–14 in Taiwanese families |
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| Authors: | Chih‐Min Liu Ming‐Wei Lin Wen‐Chen Ou‐Yang Sandy F.‐C. Lee Cathy S.J. Fann Su‐Hsien Wong Shu‐Hua Hsieh |
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| Affiliation: | 1. Department of Psychiatry, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan;2. Department of Medical Research and Education, Veterans General Hospital, Taipei, Taiwan;3. Chianan Psychiatric Center, Department of Health, Tainan, Taiwan;4. Institute of Public Health, National Yang‐Ming University, Tapei, Taiwan;5. Taoyuan Psychiatric Center, Taoyuan, Taiwan;6. Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan |
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| Abstract: | ![]()
In order to evaluate the linkage of schizophrenia to loci at chromosome 15q, we genotyped six microsatellite markers at chromosome 15q11–14 in 52 Taiwanese schizophrenic families. Two phenotype models (narrow: DSM‐IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other nonaffective psychotic disorders) were used to define the disease phenotype. Maximum nonparametric linkage scores (NPL scores) of 3.33 (P = 0.0003) and 2.96 (P = 0.0008) were obtained at the marker D15S976 under broad and narrow models, respectively. Positive linkage results were also observed at the marker D15S1360, previously reported to have significant linkage to a neurophysiological deficit of schizophrenia, with NPL scores of 2.71 (P = 0.003) and 2.78 (P = 0.002) under broad and narrow models, respectively. The results provide suggestive linkage evidence of schizophrenia to loci at chromosome 15q13–14 in an ethnically distinct Taiwanese sample. © 2001 Wiley‐Liss, Inc. |
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| Keywords: | schizophrenia linkage chromosome 15q |
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