阿托伐他汀对老年原发性高血压患者血管内皮功能的影响

目的探讨阿托伐他汀对老年原发性高血压患者血管内皮功能的影响.方法观察40例老年原发性高血压患者(治疗组)经阿托伐他汀每日1次10 mg治疗8周后,血脂、血浆内皮素(ET)水平的变化,并用超声检测肱动脉血管内皮依赖性舒张功能(EDD)的变化.选择15例健康老年人(对照组)做为对照.结果治疗组血浆ET水平明显高于对照组,血管内皮依赖性舒张功能受损,治疗后ET血浆水平明显下降(P＜0.01),EDD明显改善(P＜0.01),且ET和EDD改善与LDL-C下降程度无相关性.结论阿托伐他汀可以改善老年原发性高血压患者血管内皮的功能,且独立于降脂作用之外.

Effect of atrovastatin on vascular endothelium function in geriatric hypertension

Objective To assess the effect of atrovastatin on vascular endothelium function in geriatric hypertensive patients. Methods Forty essential hypertension patients aged 66 or older were treated with atrovastatin (10 mg/d) for 8 weeks. 15 healthy geriatric adults served as control. Endothelial dependent dilation (EDD) in brachial artery were measured by Doppler ultrasound before and after treatment. Blood lipids, plasma ET were also measured. Results The vascular EDD was impaired in geriatric hypertension, and plasma ET was significant higher than control group before treatment(P<0.01). After 8 weeks treatment of atrovastatin, plasma ET was significantly reduced (P<0.01) and flow-mediated vasodilation improved (P<0.01).The improvement of EDD and the reduction of plasma ET were independent of low density lipoprotein cholesterol (LDL-C) reduction in hypertensive patients (P>0.05). Conclusion Treatment with atrovastatin can produce a protective effect on vascular endothelium function in geriatric hypertensives, which is independent of its lipid-lowering effects.