Plasmid Copy Number and Disease Severity in Naturally Occurring Ocular Chlamydia trachomatis Infection |
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| Authors: | Anna R. Last Chrissy h. Roberts Eunice Cassama Meno Nabicassa Sandra Molina-Gonzalez Sarah E. Burr David C. W. Mabey Robin L. Bailey Martin J. Holland |
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| Affiliation: | aClinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom;bPrograma Nacional de Saúde de Visão, Ministério de Saúde Publica, Bissau, Guinea Bissau;cDisease Control and Elimination Theme, Medical Research Council Unit The Gambia, Fajara, The Gambia |
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| Abstract: | The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]) and there were no associations with C. trachomatis load or disease severity. |
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