| 氯化钐、氯化镨对大鼠肝脏形态及LPO、SOD活性的影响 |
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| 引用本文： | 崔丽,刘晓玲,聂毓秀, 李岩.氯化钐、氯化镨对大鼠肝脏形态及LPO、SOD活性的影响[J].吉林大学学报(医学版),1994(4). |
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| 作者姓名： | 崔丽 刘晓玲 聂毓秀 李岩 |
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| 作者单位： | 吉林医学院 |
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| 摘 要： | 本实验采用不同途径给予断乳Ｗｉｓｔａｒ大鼠小剂量（０．０５ｍｇ／ｋｇ、０．０２５ｍｇ／ｋｇ）氯化角钐（ＳｍＣｌ３）、氯化镨（ＰｒＣｌ３）后，测定了肝脏中过氧化脂质（ＬＰＯ）和超氧化物歧化酶（ＳＯＤ）的含量，观察了肝脏的超微结构。结果表明：ＳｍＣｌ３和ＰｒＣｌ３均使肝脏中ＬＰＯ活性降低、ＳＯＤ活性升高，二者比较ＰｒＣｌ３的作用更为明显，肝脏未见明显形态学改变。
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| 关 键 词： | 氯化物类／药理学，氯化物类／投药和剂量，肝脏／超微结构，过氧化脂质／代谢，超氧化物歧化酶／代谢 |
Effect of SmCl3 and PrCl3 on morphology of liver and activities of LP0 and S0D in rats |
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| Cui Li,Li Yan,Liu Xiao Ling,Nic Yuxiu.Effect of SmCl3 and PrCl3 on morphology of liver and activities of LP0 and S0D in rats[J].Journal of Jilin University: Med Ed,1994(4). |
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| Authors: | Cui Li Li Yan Liu Xiao Ling Nic Yuxiu |
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| Abstract: | In this paper the ablactatcd Wistar rats were used
and small doses(0.05mg/kg,0. 025mg/kg)of SmCl3 and PrCl3 were given in different ways.The
activity of LPO and SOD inrat liver was measured and the morphological changes in the liver
were observed with light andclectron microscope, The results showed that both SmCl3 and
PrCl3 could decrease the activity ofPO and increase the activity of SOD, but the effects of PrCl3
was better than that of SmCl3 . Noobvious,morphologica changes in the liver were observed。 |
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| Keywords: | chlorides/pharmocology chlorides/administration& dosage liver/ultrasono-graphy lipid peroxides/metabolism superoxide dismutase/metabolism |
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