宁夏南部山区儿童先天性心脏病发生的危险因素分析

目的探讨与宁夏南部山区儿童先天性心脏病（CHD）发生有关的环境危险因素。方法采用1∶病例对照研究方法,对病例组和对照组患儿的父母亲发放统一问卷,采用单因素分析及多因素Logistic回归分析方法对21个变量进行分析。结果共调查了113名病例和113名对照,运用检验,按a=0.05水准,从21个可能危险因素中筛选出8个变量,将8个变量引入Logistic回归模型,最终筛选出5个危险因素,按照影响由强到弱的顺序依次为母亲孕早期感冒史、母亲孕期被动吸烟史、母亲孕期有害物质接触史、母亲孕早期不良精神因素、父亲有害物质接触史。结论应加强孕前父母亲的健康教育、孕期保健,以减少危险因素的接触。

Analysis on the risk factors of congenital heart disease in children in Ningxia southern area

Objective To explore the risk factors of congenital heart disease（CHD） in children in Ningxia southern area,and to provide scientific guidelines for prevention of CHD.Methods One to one matched case-control study was designed,in which cases and controls direct parents were retrospectively interviewed with the same questionnaire.Conduct univariate analysis to filter all the research factors.Results 113 cases and 113 controls were investigated and information collected.8 suspicious risk factors entered the analysis of multivariate unconditional Logistic regression after X^2. The analysis results showed that 5 factors were significantly associated with the risky factors of CHD. These 5 risk factors were ： fever during early pregnancy, maternal passive smoking during early pregnancy, maternal exposure to harmful substance, maternal mental stress during pregnancy, patrilineal exposure to harmful substance. Conclusion The health education and antenatal care to parents before pregnancy should be carried out widely. It is important to get away from risk factors and improve population quality